Atp6ap2^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Atp6ap2^tm1.1Ics
• Name: ATPase, H+ transporting, lysosomal accessory protein 2; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5776594
• Synonyms: Atp6ap2^cKO, Atp6ap2^tm1.1Gvng, PRR^flox
• Gene: Atp6ap2 Location: ChrX:12454040-12483288 bp, + strand Genetic Position: ChrX, 7.42 cM
• Alliance: Atp6ap2^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232697
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. An FRT site remains in intron 2 from removal of the selection cassette. (J:232697)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp6ap2 Mutation: 10 strains or lines available

References

• Original: J:232697 Riediger F, et al., Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol. 2011 Dec;22(12):2193-202
• All: 15 reference(s)