Ap2b1em1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Ap2b1em1(IMPC)J |
Name: |
adaptor-related protein complex 2, beta 1 subunit; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:5776619 |
Synonyms: |
Ap2b1em1J |
Gene: |
Ap2b1 Location: Chr11:83189850-83295861 bp, + strand Genetic Position: Chr11, 50.3 cM, cytoband B5
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Alliance: |
Ap2b1em1(IMPC)J page
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IMPC: |
Ap2b1 gene page |
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intergenic deletion
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Mutation details: This allele from project Ap2b1-7740J-M6562 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences ACAAGGCAGCCACTGAAGTA, TTGCAATATAAAATACCATC, GTAAGGGCTGACTGTCCATA and AAGGGCTGACTGTCCATAGG, which resulted in a 247 bp deletion of exon 3 beginning at Chromosome 11 positive strand position 83,316,316 bp, CTTACTTCAGTGGCTGCCTT, and ending after CCCCCCTATGGACAGTCAGC at 83,316,562 bp (GRCm38/mm10). This mutation deletes exon 3 and 141 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 12 and early truncation 7 amino acids later.
(J:188991)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
3 reference(s) |
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