Rrm1^tm1.1Ofc
Targeted Allele Detail

Summary

• Symbol: Rrm1^tm1.1Ofc
• Name: ribonucleotide reductase M1; targeted mutation 1.1, Oscar Fernandez-Capetillo
• MGI ID: MGI:5776729
• Synonyms: Rrm1^WG
• Gene: Rrm1 Location: Chr7:102090902-102118978 bp, + strand Genetic Position: Chr7, 54.72 cM
• Alliance: Rrm1^tm1.1Ofc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228239
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct inserted a point mutation that results in the amino acid substitution of glycine for tryptophan at position 688 (W688G). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of the point mutation. (J:228239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rrm1 Mutation: 41 strains or lines available

References

• Original: J:228239 Specks J, et al., A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development. Mol Cell Biol. 2015 Sep 1;35(17):2910-7
• All: 1 reference(s)