Igfbp5^{tm1(icre/ERT2)Murr}
Targeted Allele Detail

Summary

• Symbol: Igfbp5^{tm1(icre/ERT2)Murr}
• Name: insulin-like growth factor binding protein 5; targeted mutation 1, Stephen Murray
• MGI ID: MGI:5779503
• Gene: Igfbp5 Location: Chr1:72897224-72914024 bp, - strand Genetic Position: Chr1, 36.94 cM
• Alliance: Igfbp5^{tm1(icre/ERT2)Murr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259166
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Igfbp5^{tm1(icre/ERT2)Murr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Igfbp5 (MGI:96440)

• Mutation details: An IRES-icre/ERT2 cassette was inserted 6 bp (AGTACT) downstream of exon 4 and an FRT flanked neomycin resistance cassette was inserted into the intron between exons 3 and 4, and this allele derived from clone 2A10. (J:259166)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Igfbp5 (mouse) Summary of all recombinase alleles driven by Igfbp5. Comparative matrix view of recombinase activities Alliance mouse Igfbp5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igfbp5 Mutation: 20 strains or lines available

References

• Original: J:259166 Seidel K, et al., Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis. Elife. 2017 May 5;6:e24712
• All: 1 reference(s)