Tg(PMP22-tTA)JY13Clh
Transgene Detail

Summary

• Symbol: Tg(PMP22-tTA)JY13Clh
• Name: transgene insertion JY13, Clare Huxley
• MGI ID: MGI:5779547
• Synonyms: JY13, TgN(PMPtTA)JY13Clh
• Transgene: Tg(PMP22-tTA)JY13Clh Location: unknown
• Alliance: Tg(PMP22-tTA)JY13Clh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The tTA open reading frame was introduced into the second exon of the human PMP22 gene on YAC 49G7 such that the start of translation of the PMP22 gene is used to start the tTA ORF. The PMP22 genen on the YAC is disrupted and is not expressed. tTA is expressed in Schwann cells. (J:69545)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69545 Perea J, et al., Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A. Hum Mol Genet. 2001 May 1;10(10):1007-18
• All: 1 reference(s)