Pik3c2a^tm1Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3c2a^tm1Bvan
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; targeted mutation 1, Bart Vanhaesebroeck
• MGI ID: MGI:5779550
• Synonyms: PI3K-C2alpha (D1268A)
• Gene: Pik3c2a Location: Chr7:115936500-116042684 bp, - strand Genetic Position: Chr7, 61.62 cM
• Alliance: Pik3c2a^tm1Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The allele contained nucleotide substitution(s) that result(s) in the amino acid substitution of alanine for aspartic acid at position 1268 (D1268A). This mutation inactivates the kinase. Heterozygous mutant mice show normal mRNA levels in megakaryocytes and normal protein expression in platelets relative to wild-type controls. In vitro platelet lipid kinase activity is reduced by 50% relative to wild-type controls. (J:226344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pik3c2a Mutation: 99 strains or lines available

References

• Original: J:226344 Valet C, et al., Essential role of class II PI3K-C2alpha in platelet membrane morphology. Blood. 2015 Aug 27;126(9):1128-37
• All: 2 reference(s)