Mcu^tm1.1Jmol
Targeted Allele Detail

Summary

• Symbol: Mcu^tm1.1Jmol
• Name: mitochondrial calcium uniporter; targeted mutation 1.1, Jeffery Molkentin
• MGI ID: MGI:5779563
• Synonyms: Mcu^fl
• Gene: Mcu Location: Chr10:59282806-59452514 bp, - strand Genetic Position: Chr10, 29.55 cM
• Alliance: Mcu^tm1.1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac x C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 5 and 6 were floxed. Flp-mediated recombination removed a neomycin resistance cassette. (J:224853)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mcu Mutation: 27 strains or lines available

References

• Original: J:224853 Kwong JQ, et al., The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Rep. 2015 Jul 7;12(1):15-22
• All: 28 reference(s)