Rab7^tm1.2Ale
Targeted Allele Detail

Summary

• Symbol: Rab7^tm1.2Ale
• Name: RAB7, member RAS oncogene family; targeted mutation 1.2, Aimee Edinger
• MGI ID: MGI:5779674
• Gene: Rab7 Location: Chr6:87976088-88022252 bp, - strand Genetic Position: Chr6, 39.13 cM
• Alliance: Rab7^tm1.2Ale page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211733
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 1, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 1. Cre-mediated recombination removed the neo cassette and exon 1. (J:211733)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab7 Mutation: 121 strains or lines available

References

• Original: J:211733 Roy SG, et al., Reciprocal effects of rab7 deletion in activated and neglected T cells. Autophagy. 2013 Jul;9(7):1009-23
• All: 1 reference(s)