Tmx2^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Tmx2^{tm1.1(KOMP)Vlcg}
• Name: thioredoxin-related transmembrane protein 2; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5779820
• Synonyms: Tmx2^-
• Gene: Tmx2 Location: Chr2:84501655-84509172 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: Tmx2^{tm1.1(KOMP)Vlcg} page
• IMPC: Tmx2 gene page

Tmx2^{tm1.1(KOMP)Vlcg}/Tmx2^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and never reach blastocyst stage in culture.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 10209A-A10
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 5670bp between positions 84512524-84518193 of Chromosome 2 (Genome Build37) and subsequent Cre-mediated excision deleted the neomycin selection cassette. (J:136110, J:188991)

Expression

In Mice Carrying this Mutation:

59 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmx2 Mutation: 11 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 5 reference(s)