Fam181b^tm1.2Lswr
Targeted Allele Detail

Summary

• Symbol: Fam181b^tm1.2Lswr
• Name: family with sequence similarity 181, member B; targeted mutation 1.2, Lars Wittler
• MGI ID: MGI:5780054
• Gene: Fam181b Location: Chr7:92729087-92730929 bp, + strand Genetic Position: Chr7, 51.66 cM
• Alliance: Fam181b^tm1.2Lswr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228526
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the open reading frame. A V5 epitope tag was inserted fused with the open reading frame. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette with a 3' loxP site inserted into the 3' UTR. Cre-mediated recombination removed the open reading frame. (J:228526)

Expression

In Mice Carrying this Mutation:

22 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fam181b Mutation: 8 strains or lines available

References

• Original: J:228526 Marks M, et al., Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene. 2016 Jan 10;575(2 Pt 2):438-51
• All: 1 reference(s)