Nexn^tm1.1Zhh
Targeted Allele Detail

Summary

• Symbol: Nexn^tm1.1Zhh
• Name: nexilin; targeted mutation 1.1, Zouhair Aherrahrou
• MGI ID: MGI:5780982
• Gene: Nexn Location: Chr3:151942619-151971987 bp, - strand Genetic Position: Chr3, 77.07 cM
• Alliance: Nexn^tm1.1Zhh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228046
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and downstream of exon 4. Cre-mediated recombination removed exons 2 through 4. Western blot analysis confirmed the absence of protein expression. Western blot analysis confirmed the absence of protein expression in the heart. (J:228046)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nexn Mutation: 28 strains or lines available

Notes

ES cell line = 2066 A-F9 (strain not specified)

References

• Original: J:228046 Aherrahrou Z, et al., Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. Basic Res Cardiol. 2016 Jan;111(1):6
• All: 2 reference(s)