Ddit3^tm1.1Irt
Targeted Allele Detail

Summary

• Symbol: Ddit3^tm1.1Irt
• Name: DNA-damage inducible transcript 3; targeted mutation 1.1, Ira Tabas
• MGI ID: MGI:5781019
• Synonyms: Chop^F, Chop^fl, Ddit3^fl
• Gene: Ddit3 Location: Chr10:127126662-127132160 bp, + strand Genetic Position: Chr10, 74.5 cM
• Alliance: Ddit3^tm1.1Irt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233223
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Using a bacteria artificial chromosome (BAC), exon 3 of the gene was flanked with a loxP site and a Frt-Neo-Frt-loxP cassette. Flpe-mediated recombination removed the neo cassette. (J:233223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddit3 Mutation: 20 strains or lines available

Notes

ES Cell line = CSL2J2 (B6(Cg)-Tyr/J).

References

• Original: J:233223 Zhou AX, et al., C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circ Res. 2015 May 22;116(11):1736-43
• All: 13 reference(s)