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Elk3tm1.2Ics
Targeted Allele Detail
Summary
Symbol: Elk3tm1.2Ics
Name: ELK3, member of ETS oncogene family; targeted mutation 1.2, Mouse Clinical Institute
MGI ID: MGI:5781314
Synonyms: Elk3-
Gene: Elk3  Location: Chr10:93083276-93146997 bp, - strand  Genetic Position: Chr10, 48.04 cM, cytoband C-D1
Alliance: Elk3tm1.2Ics page
Delayed retinal angiogenesis during early postnatal stages in Elk3tm1.2Ics/Elk3tm1.2Ics mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221521
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1. (J:221521)
Generation of the Elk3tm1.1Ics and Elk3tm1.2Ics alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elk3 Mutation:  20 strains or lines available
References
Original:  J:221521 Weinl C, et al., Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae. PLoS One. 2014;9(9):e107048
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory