Tg(tetO-NRG1_i4)6Ajla
Transgene Detail

Summary

• Symbol: Tg(tetO-NRG1_i4)6Ajla
• Name: transgene insertion 6, Amanda J Law
• MGI ID: MGI:5784536
• Synonyms: NRGI-IV
• Transgene: Tg(tetO-NRG1_i4)6Ajla Location: unknown
• Alliance: Tg(tetO-NRG1_i4)6Ajla page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-NRG1_i4)6Ajla expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NRG1 (3084)

  Nrg1	(MGI:96083)

  cDNA contains isoform IV

• Mutation details: The tetracycline responsive promoter drives inducible expression of the human isoform IV cDNA. Two lines, 6 and 13 were described. Line 6 is entered as the representative line. (J:231737)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:231737 Papaleo F, et al., Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model. J Neurosci. 2016 Apr 27;36(17):4859-75
• All: 1 reference(s)