Kdm2b^tm1.1Bes
Targeted Allele Detail

Summary

• Symbol: Kdm2b^tm1.1Bes
• Name: lysine (K)-specific demethylase 2B; targeted mutation 1.1, Timothy H Bestor
• MGI ID: MGI:5784548
• Synonyms: Fbxl10-2^flox
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^tm1.1Bes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233372
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 1 (including the alternative internal promoter) followed by a second loxP site and an FRT-flanked neomycin resistance (neo) cassette downstream of exon 1 of isoform 2. This region corresponds to intron 12 in the Kdm2b isoform 1 gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:233372)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 219 strains or lines available

References

• Original: J:233372 Boulard M, et al., Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10. Epigenetics Chromatin. 2016;9:22
• All: 1 reference(s)