Scram1^129S4/SvJae
QTL Variant Detail

Summary

• QTL variant: Scram1^129S4/SvJae
• Name: spinal cord resistance to astrocytoma modifier 1; 129S4/SvJae
• MGI ID: MGI:5784562
• QTL: Scram1 Location: Chr5:138455402-138455402 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: 129S4/SvJae

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:178603

Linkage analysis was performed on a mapping population of 88 (129S/Sv-Trp53^tm1TyJ Nf1^tm1Tyj/+ + x C57BL/6J)F1 x 129S4/SvJae mice (37 females and 51 males) to identify genomic loci related to spinal cord resistance for astrocytoma. Mice were genotyped at 880 informative SNP markers (mouse genome build 37.1; mm9).

QTL Scram1 (spinal cord resistance to astrocytoma modifier 1) maps to Chromosome 5 between 129.0 - 152.5 Mb (from 67.26 cM to the distal end of Chromosome 5) with a peak LOD score of 5.03 at 77.26 cM (rs4225536). Mice heterozygous for C57BL/6J x 129S4/SvJae at the Scram1 locus show less astrocytoma in the spinal cord compared to 129S4/SvJae homozygous mice, although authors have shown previously that 129S4/SvJae mice are more resistant to astrocytoma than C57BL/6J.

J:178603

Linkage analysis was performed on a mapping population of 88 (129S/Sv-Trp53^tm1TyJ Nf1^tm1Tyj/+ + x C57BL/6J)F1 x 129S4/SvJae mice (37 females and 51 males) to identify genomic loci related to spinal cord resistance for astrocytoma. Mice were genotyped at 880 informative SNP markers (mouse genome build 37.1; mm9).

QTL Scram1 (spinal cord resistance to astrocytoma modifier 1) maps to Chromosome 5 between 129.0 - 152.5 Mb (from 67.26 cM to the distal end of Chromosome 5) with a peak LOD score of 5.03 at 77.26 cM (rs4225536). Mice heterozygous for C57BL/6J x 129S4/SvJae at the Scram1 locus show less astrocytoma in the spinal cord compared to 129S4/SvJae homozygous mice, although authors have shown previously that 129S4/SvJae mice are more resistant to astrocytoma than C57BL/6J. This finding suggests that the C57BL/6J allele confers resistance to astrocytoma in the spinal cord at the Scram1 locus.

References

• Original: J:178603 Amlin-Van Schaick J, et al., Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5. Mamm Genome. 2012 Apr;23(3-4):277-85
• All: 1 reference(s)