Sav1^tm1.1Gpp
Targeted Allele Detail

Summary

• Symbol: Sav1^tm1.1Gpp
• Name: salvador family WW domain containing 1; targeted mutation 1.1, Gerd P Pfeifer
• MGI ID: MGI:5784888
• Gene: Sav1 Location: Chr12:70011786-70033776 bp, - strand Genetic Position: Chr12, 28.94 cM, cytoband C3
• Alliance: Sav1^tm1.1Gpp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a floxed neomycin resistance cassette. Cre-mediated recombination was used to remove the neo cassette. (J:231761)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sav1 Mutation: 20 strains or lines available

References

• Original: J:231761 Zhang X, et al., Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1. Cancer Res. 2016 May 1;76(9):2824-35
• All: 1 reference(s)