Mogat1^tm1Far
Targeted Allele Detail

Summary

• Symbol: Mogat1^tm1Far
• Name: monoacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese
• MGI ID: MGI:5785005
• Gene: Mogat1 Location: Chr1:78487628-78514810 bp, + strand Genetic Position: Chr1, 40.59 cM, cytoband C4
• Alliance: Mogat1^tm1Far page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231617
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neo cassette. Deletion of this exon is predicted to result in a frame shift. Northern blot analysis confirmed expression of a smaller than normal transcript in the kidney. Enzymatic assays failed to detect MGAT activity in the kidney. (J:231617)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mogat1 Mutation: 22 strains or lines available

References

• Original: J:231617 Agarwal AK, et al., Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr;57(4):616-30
• All: 1 reference(s)