Atp1b1^tm1.1Zboro
Targeted Allele Detail

Summary

• Symbol: Atp1b1^tm1.1Zboro
• Name: ATPase, Na+/K+ transporting, beta 1 polypeptide; targeted mutation 1.1, Zea Borok
• MGI ID: MGI:5787934
• Synonyms: Atp1b1^F
• Gene: Atp1b1 Location: Chr1:164264678-164285924 bp, - strand Genetic Position: Chr1, 71.75 cM
• Alliance: Atp1b1^tm1.1Zboro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233742
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 4, and a FRT-flanked neomycin resistance (neo) cassette, in opposite orientation to the gene, followed by a second loxP site, downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. (J:233742)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp1b1 Mutation: 20 strains or lines available

References

• Original: J:233742 Flodby P, et al., Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 Sep;55(3):395-406
• All: 1 reference(s)