Fbxl12^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxl12^tm1Kei
• Name: F-box and leucine-rich repeat protein 12; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:5788017
• Gene: Fbxl12 Location: Chr9:20549045-20556064 bp, - strand Genetic Position: Chr9, 7.59 cM, cytoband A3
• Alliance: Fbxl12^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228662
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All three exons were replaced with an IRES, lacZ reporter gene and floxed neomycin resistance cassette. (J:228662)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxl12 Mutation: 28 strains or lines available

References

• Original: J:228662 Nishiyama M, et al., FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Stem Cells. 2015 Nov;33(11):3327-40
• All: 1 reference(s)