Or8a1^{tm43(Or8a1)Mom}
Targeted Allele Detail

Summary

• Symbol: Or8a1^{tm43(Or8a1)Mom}
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 43, Peter Mombaerts
• MGI ID: MGI:5788157
• Synonyms: M71-M71-GFP, Olfr151^{tm39(Olfr151)Mom}
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^{tm43(Or8a1)Mom} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233447
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Duplication, Insertion
• Mutation details: An internal ribosome entry sequence (IRES) followed by a second sequence encoding Olfr151 followed by a second IRES followed by GFP was inserted just downstream of the endogenous coding sequence of Olfr151, resulting in tricistronic expression that yields 2 copies of Olfr151 and one copy of GFP to double the expression level of Olfr151 from one allele. (J:233447)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:233447 Movahedi K, et al., Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biol. 2016 Jul;6(7)
• All: 1 reference(s)