Tg(tetO-MAPT*A152T)L1Lms
Transgene Detail

Summary

• Symbol: Tg(tetO-MAPT*A152T)L1Lms
• Name: transgene insertion L1, Lennart Mucke
• MGI ID: MGI:5788163
• Synonyms: hTau-A152T, TRE-hTau-A152T
• Transgene: Tg(tetO-MAPT*A152T)L1Lms Location: unknown
• Alliance: Tg(tetO-MAPT*A152T)L1Lms page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-MAPT*A152T)L1Lms expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  with mutation A152T

• Mutation details: A transgenic construct containing cDNA of the human MAPT gene encoding the 1N4R isoform, with upstream intronic sequence (from pCI-neo vector) and a Kozak sequence, and downstream bovine growth hormone polyadenylation sequence, all under the control of the tetO, a tetracycline-responsive regulatory element (pTRE-Tight). The 1N4R isoform of human MAPT (microtubule-associated protein tau) contains an A152T substitution, converting GCC (Ala) at positions 454-456 to ACC (Thr). Founder line C11-1, also known as founder line L1, was established. (J:233816)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:233816 Maeda S, et al., Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016 Apr;17(4):530-51
• All: 3 reference(s)