Gt(ROSA)26Sor^tm5Mom
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm5Mom
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Peter Mombaerts
• MGI ID: MGI:5788276
• Synonyms: RoMo-dnGs
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm5Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233447
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Dominant negative, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A construct was inserted between exons 1 and 2 of this locus that encodes the CAG promoter followed by a loxP flanked a B-geo-STOP cassette followed by a loxN site then a Tau-mTurquoise sequence and woodchuck hepatitis post-transcriptional regulatory element (WPRE) followed by a lox2272 then a loxN site followed by a Tau-tdTomato sequence immediately followed by an IRES and dominant negative Gnas sequence a WPRE and lox2272 site. This allele can be cre-induced to generate stochastic expression of either Tau-Turquoise alone or Tau-tdTomato along with the dominant negative GNAS. (J:233447)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:233447 Movahedi K, et al., Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biol. 2016 Jul;6(7)
• All: 1 reference(s)