Gabra5^tm2.1Uru
Targeted Allele Detail

Summary

• Symbol: Gabra5^tm2.1Uru
• Name: gamma-aminobutyric acid type A receptor subunit alpha 5; targeted mutation 2.1, Uwe Rudolph
• MGI ID: MGI:5788282
• Gene: Gabra5 Location: Chr7:57057420-57159807 bp, - strand Genetic Position: Chr7, 33.52 cM
• Alliance: Gabra5^tm2.1Uru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226464
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 4 and 5 were flanked by loxP sites. The selectable markers were removed in vitro. (J:226464)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabra5 Mutation: 33 strains or lines available

References

• Original: J:226464 Engin E, et al., Tonic Inhibitory Control of Dentate Gyrus Granule Cells by alpha5-Containing GABAA Receptors Reduces Memory Interference. J Neurosci. 2015 Oct 7;35(40):13698-712
• All: 4 reference(s)