Tg(Tyr,Col1a1-Trps1)1Brle
Transgene Detail

Summary

• Symbol: Tg(Tyr,Col1a1-Trps1)1Brle
• Name: transgene insertion 1, Brendan Lee
• MGI ID: MGI:5788285
• Synonyms: Tg1
• Transgene: Tg(Tyr,Col1a1-Trps1)1Brle Location: unknown
• Alliance: Tg(Tyr,Col1a1-Trps1)1Brle page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tyr,Col1a1-Trps1)1Brle expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trps1 (MGI:1927616)

• Mutation details: The full-length murine V5-tagged Trps1 cDNA is under the control of the osteoblast and odentoblast specific 2.3-kb fragment of the collagen type I promoter. In addition a cassette containing the tyrosinase cDNA expressed from its endogenous promoter independently of Trps1 expression is upstream of the Col1a1 promoter. Seven lines were generated. Line 1 is the high expressing line, with mRNA levels in calvaria 15 times higher than wild-type littermates. (J:233272)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Dentinogenesis Imperfecta J:233272

References

• Original: J:233272 Napierala D, et al., Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice. J Bone Miner Res. 2012 Aug;27(8):1735-45
• All: 3 reference(s)