Cdc37l1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdc37l1^em1(IMPC)J
• Name: cell division cycle 37-like 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5788403
• Synonyms: Cdc37l1^em1J
• Gene: Cdc37l1 Location: Chr19:28967752-29004081 bp, + strand Genetic Position: Chr19, 23.61 cM, cytoband C2
• Alliance: Cdc37l1^em1(IMPC)J page
• IMPC: Cdc37l1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Cdc37l1-7867J-M7730 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GACCAGTGTGATACATGACA, GTATTGCCTCACAGAAAGAA, CATTATTTACCTTAAATGAG and CATTATTTACCTTAAATGAG, which resulted in a 273 bp deletion beginning at Chromosome 19 negative strand position 29,007,109 bp, ACATTCAAGGTTCATACAGT, and ending after ACATGACAGGGCAAGCCGAG at 29,006,837 bp (GRCm38/mm10). This mutation deletes exon 4 and 157 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 168 and early truncation 48 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdc37l1 Mutation: 52 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)