Tg(Tyr,Col2a1-Trpv4*R594H)#Dhco
Transgene Detail

Summary

• Symbol: Tg(Tyr,Col2a1-Trpv4*R594H)#Dhco
• Name: transgene insertion, Daniel H Cohn
• MGI ID: MGI:5788532
• Synonyms: Trpv4^R594H
• Transgene: Tg(Tyr,Col2a1-Trpv4*R594H)#Dhco Location: unknown
• Alliance: Tg(Tyr,Col2a1-Trpv4*R594H)#Dhco page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tyr,Col2a1-Trpv4*R594H)#Dhco expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trpv4 (MGI:1926945)

• Mutation details: The mouse Trpv4 cDNA with the R594H mutation containing an in-frame consensus Kozak translation initiation sequence is under the control of the Col2a1 promoter. In addition a K14-Tyrosinase reporter minigene is independently expressed via the tyrosinase promoter. (J:233234)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:233234 Weinstein MM, et al., Mice expressing mutant Trpv4 recapitulate the human TRPV4 disorders. J Bone Miner Res. 2014 Aug;29(8):1815-22
• All: 1 reference(s)