Arhgef11^tm1.1Mak
Targeted Allele Detail

Summary

• Symbol: Arhgef11^tm1.1Mak
• Name: Rho guanine nucleotide exchange factor 11; targeted mutation 1.1, Tak Mak
• MGI ID: MGI:5788572
• Synonyms: PDZ-RhoGEF KO
• Gene: Arhgef11 Location: Chr3:87524866-87645341 bp, + strand Genetic Position: Chr3, 38.22 cM
• Alliance: Arhgef11^tm1.1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233950
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site, followed by an FRT site, a neomycin selection cassette, a second loxP site and an FRT site are inserted upstream of exon 2, and a third loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2. Western blot and immunoblot analysis confirms that no protein was expressed in mutant mice. (J:233950)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arhgef11 Mutation: 77 strains or lines available

References

• Original: J:233950 Chang YJ, et al., The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes. Elife. 2015;4:e06011
• All: 1 reference(s)