Ip6k3^tm1.1Snyd
Targeted Allele Detail

Summary

• Symbol: Ip6k3^tm1.1Snyd
• Name: inositol hexaphosphate kinase 3; targeted mutation 1.1, Solomon Snyder
• MGI ID: MGI:5788648
• Gene: Ip6k3 Location: Chr17:27362945-27386738 bp, - strand Genetic Position: Chr17, 13.77 cM
• Alliance: Ip6k3^tm1.1Snyd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225876
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is an cre/loxP-induced intragenic deletion of the splice site, coding region, and the 3'UTR of exon 6. Immunostaining revealed substantial levels in cortex, hippocampus, thalamus, hypothalamus, and cerebellum with virtually total loss of the enzyme in homozygous mutant mice. (J:225876)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ip6k3 Mutation: 22 strains or lines available

References

• Original: J:225876 Fu C, et al., Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin. J Neurosci. 2015 Aug 5;35(31):11056-67
• All: 3 reference(s)