Bbs10^tm1.2Vmar
Targeted Allele Detail

Summary

• Symbol: Bbs10^tm1.2Vmar
• Name: Bardet-Biedl syndrome 10; targeted mutation 1.2, Vincent Marion
• MGI ID: MGI:5788680
• Synonyms: Bbs10^-
• Gene: Bbs10 Location: Chr10:111134540-111137588 bp, + strand Genetic Position: Chr10, 58.46 cM
• Alliance: Bbs10^tm1.2Vmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227230
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A koxP site was inserted upstream of the 2-exon gene and a second loxP site, an FRT site, a neomycin selection cassette, a third loxP site and a second FRT site were inserted downstream of the gene. The neo cassette was removed through subsequent Flp-mediated recombination and the gene was deleted through Cre-mediated recombination. No detectable mRNA is expressed from this allele in samples derived from kidney and eye of homozygous mice. (J:227230)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bbs10 Mutation: 35 strains or lines available

References

• Original: J:227230 Cognard N, et al., Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice. Cilia. 2015;4:10
• All: 3 reference(s)