Sgta^tm1.1Drmcr
Targeted Allele Detail

Summary

• Symbol: Sgta^tm1.1Drmcr
• Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; targeted mutation 1.1, Dame Roma Mitchell Cancer Research
• MGI ID: MGI:5788683
• Gene: Sgta Location: Chr10:80879909-80896015 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sgta^tm1.1Drmcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234007
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP upstream of exon 4 (containing the start codon), and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 5 gene. Cre-mediated recombination removed exons 4 through 5 and the neo cassette. Western blot and immunohistochemistry of prostrate and ovary confirmed that no protein was expressed in mutant mice. (J:234007)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgta Mutation: 19 strains or lines available

References

• Original: J:234007 Philp LK, et al., Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice. Sci Rep. 2016;6:28950
• All: 1 reference(s)