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Snap91tm1.1Tmar
Targeted Allele Detail
Summary
Symbol: Snap91tm1.1Tmar
Name: synaptosomal-associated protein 91; targeted mutation 1.1, Tanja Maritzen
MGI ID: MGI:5788722
Synonyms: AP180-
Gene: Snap91  Location: Chr9:86647976-86762707 bp, - strand  Genetic Position: Chr9, 46.58 cM, cytoband E3.2
Alliance: Snap91tm1.1Tmar page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228428
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette was inserted in front of exon 3 and an additional loxP site after exon 6. Mice were mated with Ella-Cre Deleter mice to remove the neomycin resistance cassette as well as exons 3 to 6, leaving behind a single loxP site between exon 2 and 7. Western blot analysis confirmed absence of protein expression in brain lysates from adult homozygous mutant mice. (J:228428)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snap91 Mutation:  52 strains or lines available
References
Original:  J:228428 Koo SJ, et al., Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission. Neuron. 2015 Oct 21;88(2):330-44
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory