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Wdr81em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Wdr81em1(IMPC)J
Name: WD repeat domain 81; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:5788768
Synonyms: Wdr81em1J
Gene: Wdr81  Location: Chr11:75331770-75345543 bp, - strand  Genetic Position: Chr11, 45.89 cM
Alliance: Wdr81em1(IMPC)J page
IMPC: Wdr81 gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project Wdr81-7808J-F751 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences AGCCGGGGTTTGACGAACCA, CCTGGAACCCCCAAGACCTG, TGGGTTTTCTTGGGTAAGTG and CAGCGTTGAGAAGCCAGTGG, which resulted in a 290 bp deletion beginning at Chromosome 11 negative strand position 75,449,570 bp CTGGCTTCTCAACGCTGCTG, and ending after GATCCAAGGACCAGCCCCAG at 75,449,281 bp (GRCm38/mm10). This mutation deletes exon 3 and 99 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 1252 and early truncation 34 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wdr81 Mutation:  56 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory