Akna^tm2Mak
Targeted Allele Detail

Summary

• Symbol: Akna^tm2Mak
• Name: AT-hook transcription factor; targeted mutation 2, Tak Mak
• MGI ID: MGI:5788924
• Synonyms: AKNA KO2
• Gene: Akna Location: Chr4:63285362-63321591 bp, - strand Genetic Position: Chr4, 33.96 cM
• Alliance: Akna^tm2Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233952
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector uses a PGK-neo cassette to disrupt exon 3, the largest coding exon. Quantitative RT-PCR studies of spleen do not detect mRNA in homozygous mutant mice. (J:233952)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akna Mutation: 49 strains or lines available

References

• Original: J:233952 Ma W, et al., Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov;21(11):1564-77
• All: 1 reference(s)