Mh^129X1/SvJ
QTL Variant Detail

Summary

• QTL variant: Mh^129X1/SvJ
• Name: modifier of hemostasis; 129X1/SvJ
• MGI ID: MGI:5789019
• QTL: Mh Location: Chr4:65304775-65304775 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: 129X1/SvJ
• Project Collection: Sanger Inst. Gene Trap Res.

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:130782

A targeted disruption of Gp6 in mice resulted in a measurable difference in tail bleeding times in Gp6 -/- mice. The locus responsible for the difference was mapped to mouse Chromosome 4 and symbolized as Mh (modifier of hemostasis). Single nucleotide polymorphisms (SNP) were identified in 8 inbred mouse strains including C57BL/6J and 129X1/SvJ. The most significant association of the phenotype was found with SNP rs13477745 LOD 6.9 (p<.001) at bp position 64,020,437 ( v37 assembly) in mouse Chromosome 4.

References

• Original: J:130782 Cheli Y, et al., The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Blood. 2008 Feb 1;111(3):1266-73
• All: 1 reference(s)