Prdt6^A/J
QTL Variant Detail

Summary

• QTL variant: Prdt6^A/J
• Name: prion disease incubation time 6; A/J
• MGI ID: MGI:5789025
• QTL: Prdt6 Location: Chr14:4431606-6038924 bp Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

The authors determined that the Prdt6 locus is driven by the presence of a bi-allelic split present among the eight inbred founder strains of the Northport HS stock: A= A/J, AKR/J, BALB/cJ, C57BL/6J; C= C3H/HeJ, CBA/J, DBA/2J, LP/J. We have created allele records for the strains A/J and C3H/HeJ to represent the "A" and "C" allele groups, respectively.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:167733

A locus on mouse Chromosome 14 was shown as displaying an association with prion disease susceptibility incubation as indicated using Northport heterogeneous stock (HS)animals.This HS stock was derived from semi-randomly mated parental inbred strains A/J,AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J LP/J. Strain distribution patterns of the aformentioned strains indicated that a QTL region containing Prdt6 was associated with Rarb (rs48898775 exon 3, Allele test p value = .0002) and Thrb (rs16822230 Exon 6,Allele test p-value = .0005)

References

• Original: J:167733 Grizenkova J, et al., The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse. PLoS One. 2010;5(12):e15019
• All: 1 reference(s)