Inpp5j^tm1.1Cmit
Targeted Allele Detail

Summary

• Symbol: Inpp5j^tm1.1Cmit
• Name: inositol polyphosphate 5-phosphatase J; targeted mutation 1.1, Christina A Mitchell
• MGI ID: MGI:5789330
• Synonyms: Pipp^-
• Gene: Inpp5j Location: Chr11:3444375-3454821 bp, - strand Genetic Position: Chr11, 2.45 cM
• Alliance: Inpp5j^tm1.1Cmit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 and a neomycin selection cassette was deleted via Cre-mediated recombination of flanking loxP sites. Quantitative RT-PCR analysis confirmed the absence of mRNA expression in homozygous mutant brains. (J:224914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inpp5j Mutation: 41 strains or lines available

References

• Original: J:224914 Ooms LM, et al., The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell. 2015 Aug 10;28(2):155-69
• All: 1 reference(s)