Lmod2^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Lmod2^{Tn(pb-Act-RFP)1.1Zhu}
• Name: leiomodin 2 (cardiac); transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:5789380
• Synonyms: Lmod2^PB
• Gene: Lmod2 Location: Chr6:24597770-24605413 bp, + strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Lmod2^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Hypomorph)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. Line 1 contains a transposon inserted in the non-coding region of the first exon of the gene. The allele is a hypomorph, with expression in heart of 3 week old homozygous mutant animals less than 5% and 10% of controls in males and females, respectively. (J:123680, J:233669)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmod2 Mutation: 27 strains or lines available

References

• Original: J:233669 Li S, et al., Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy. Cell Biosci. 2016;6:38
• All: 2 reference(s)