Tlr4^lps-7Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr4^lps-7Btlr
• Name: toll-like receptor 4; defective lipopolysaccharide response 7 Bruce Beutler
• MGI ID: MGI:5789540
• Synonyms: cruyff
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^lps-7Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 66,840,326 (v38) on chromosome 4, or base pair 12,516 in the GenBank genomic region NC_000070. The mutation corresponds to residue 1,636 in the mRNA sequence NM_021297 within exon 3 of 3 total exons. The mutation results in an isoleucine (I) to asparagine (N) substitution at position 452 (I452N) in the protein. (J:234239)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

References

• Original: J:234239 Ochoa CD, et al., Mutagenetix entry for cruyff. MGI Direct Data Submission. 2016
• All: 1 reference(s)