Dock8^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dock8^m1Btlr
• Name: dedicator of cytokinesis 8; mutation 1, Bruce Beutler
• MGI ID: MGI:5789558
• Synonyms: snowdrop
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 25,184,941 (v38) on chromosome 19, or base pair 185,431 in the GenBank genomic region NC_000085. The effect of the mutation at the cDNA and protein levels have not examined, but the mutation is predicted to result in skipping of the 90-base pair exon 43 (out of 48 total exons), which begins after amino acid 1831 (out of 2100 total amino acids) of the protein. (J:234247)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 103 strains or lines available

References

• Original: J:234247 Choi JH, et al., Mutagenetix entry for snowdrop. MGI Direct Data Submission. 2016
• All: 2 reference(s)