Mlkl^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mlkl^m2Btlr
• Name: mixed lineage kinase domain-like; mutation 2, Bruce Beutler
• MGI ID: MGI:5789564
• Synonyms: secro
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 111,315,567 (v38) on chromosome 8, or base pair 22,890 in the GenBank genomic region NC_000074. The mutation is within intron eight, 25 base pairs away from exon 9 (out of 11 total exons). The effect of the mutation on the mRNA sequence and protein expression is unknown. In the event of exon 9 skipping, the aberrant transcript would have a deletion of the 50 base pair exon 9, leading to a frame-shift occurring after amino acid 383 of the protein (isoform 1), and termination after the inclusion of two aberrant amino acids. (J:234252)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 32 strains or lines available

Notes

Mutation is predominantly recessive.

References

• Original: J:234252 Wang Y, et al., Mutagenetix entry for secro. MGI Direct Data Submission. 2016
• All: 1 reference(s)