Socs7^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Socs7^M1Btlr
• Name: suppressor of cytokine signaling 7; mutation 1, Bruce Beutler
• MGI ID: MGI:5789572
• Synonyms: Dunn
• Gene: Socs7 Location: Chr11:97253261-97289368 bp, + strand Genetic Position: Chr11, 60.96 cM
• Alliance: Socs7^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 97,373,124 (v38) on chromosome 11 corresponding to base pair 10,829 in the GenBank genomic region NC_000077 encoding Socs7. The mutation corresponds to residue 932 in the mRNA sequence NM_138657 within exon 2 of 10 total exons. The mutation results in a phenylalanine (F) to leucine (L) substitution at position 281 (F281L) in the protein. (J:234255)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs7 Mutation: 22 strains or lines available

References

• Original: J:234255 Turer E, et al., Mutagenetix entry for Dunn. MGI Direct Data Submission. 2016
• All: 1 reference(s)