Rorc^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rorc^m3Btlr
• Name: RAR-related orphan receptor gamma; mutation 3, Bruce Beutler
• MGI ID: MGI:5789592
• Synonyms: macadamias2
• Gene: Rorc Location: Chr3:94280106-94305583 bp, + strand Genetic Position: Chr3, 40.56 cM, cytoband F2
• Alliance: Rorc^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 94,387,193 (v38) on chromosome 3, or base pair 14,479 in the GenBank genomic region NC_000069. The mutation corresponds to residue 241 in the mRNA sequence NM_011281 within exon 3 of 11 total exons and residue x in the mRNA sequence NM_001293734 within exon 2 of 10 total exons. The mutation results in a cysteine (C) to tyrosine (Y) substitution at position 48 (C48Y) in the RAR-related orphan receptor gamma (RORgamma1) protein and a cysteine to tyrosine substitution at position 27 in the RORgammat protein. (J:234257)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rorc Mutation: 44 strains or lines available

References

• Original: J:234257 Choi JH, et al., Mutagenetix entry for macadamias2. MGI Direct Data Submission. 2016
• All: 1 reference(s)