Ptpn6^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptpn6^m3Btlr
• Name: protein tyrosine phosphatase, non-receptor type 6; mutation 3, Bruce Beutler
• MGI ID: MGI:5789594
• Synonyms: candle
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 124,728,419 (v38) on chromosome 6, or base pair 10,291 in the GenBank genomic region NC_000072 encoding. The mutation corresponds to residue 866 in the mRNA sequence NM_013545 within exon 6 of 16 total exons and residue 868 in the mRNA sequence NM_001077705 within exon 6 of 16 total exons. The mutation results in an aspartic acid (D) to glycine (G) substitution at position 219 (D219G) in variant 1 and D224G in variant 2 of the protein. (J:234259)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:234259 Zhong X, et al., Mutagenetix entry for candle. MGI Direct Data Submission. 2016
• All: 1 reference(s)