Rd6m1^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Rd6m1^CAST/EiJ
• Name: retinal degeneration 6 modifier 1; CAST/EiJ
• MGI ID: MGI:5790043
• QTL: Rd6m1 Location: Chr1:158233173-158233272 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:202093

Linkage analysis was performed on a mapping population of 63 F2 homozygous Mfrp^rd6 mice from a (B6.C3Ga-Mfrp^rd6/J x CAST/EiJ) F1 intercross to identify genomic loci affecting photoreceptor cell loss in homozygous Mfrp^rd6 mice. Mice were genotyped at 100 informative SNP markers (GRCm38).

QTL Rd6m1 (retinal degeneration 6 modifier 1) maps to Chromosome 1 between 168.9 - 1124.0 Mb (54.7 - 76.3 cM) with a peak LOD score of 3.31 at 70.1 cM (D1Mit33). The CAST/EiJ allele protects against the loss of photoreceptors in homozygous Mfrp^rd6 mice.

References

• Original: J:202093 Won J, et al., Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis. Exp Eye Res. 2014 Jan;118:30-5
• All: 1 reference(s)