Mvb2^A/J
QTL Variant Detail

Summary

• QTL variant: Mvb2^A/J
• Name: modifier of vibrator 2; A/J
• MGI ID: MGI:5790048
• QTL: Mvb2 Location: Chr10:114217101-114217230 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:170900

The authors sought to identify major effect modifier loci for mouse phosphatidylinositol transfer protein a (vibrator) that bypass juvenile lethality. Linkage analysis was performed on 87 (B6.D2(Cg)-Pitpna^vb x A/J)F2-Pitpna^vb/Pitpna^vb animals using survival beyond 42 days (the maximum survival observed among B6.D2(Cg)-Pitpna^vb animals) as a dichotomous trait and using survival latency in days as a quantitative trait. Animals were drawn from two equivalent but independent crosses performed in 2003-2004 (81 vb/vb) and 2007-2008 (140 vb/vb), with similar phenotype distributions. The authors genotyped 45 long-lived (approx. 49 days) and 42 short-lived (approx 41 days) animals biased for extreme survival times and including all of the longest-lived. QTL were mapped using using microsatellite (SSLP) markers. Development of additional markers, to distinguish A/J and C57BL/6J alleles in a long segment of low divergence on chromosome 10, was guided by segments containing SNP polymorphisms in published maps (Pletcher et al. 2004). The authors identified three QTL reaching genome-wide significance:

QTL Mvb2 (modifier of vibrator 2) is significant for the dichotomous trait of survival past 42 days. It maps to Chromosome 10 with a peak LOD score at D10Mit233. Mvb2 shows a semidominant survival effect with AA > AB > BB genotypes.

QTL Mvb3 (modifier of vibrator 3) is significant for the dichotomous trait of survival past 42 days. It maps to Chromosome 3 with a peak LOD at D3Mit315. Mvb3 shows molecular heterosis with AB > AA or BB.

QTL Mvb4 (modifier of vibrator 4) is significant for the quantitative trait of survival latency. It maps to Chromosome 10 with a peak LOD at D10Mit233. Mvb4 shows a semidominant survival effect witih AA > AB > BB genotypes.

References

• Original: J:170900 Concepcion D, et al., Modifier Genes for Mouse Phosphatidylinositol Transfer Protein {alpha} (vibrator) That Bypass Juvenile Lethality. Genetics. 2011 Apr;187(4):1185-91
• All: 1 reference(s)