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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:170900The authors sought to identify major effect modifier loci for mouse phosphatidylinositol transfer protein a (vibrator) that bypass juvenile lethality. Linkage analysis was performed on 87 (B6.D2(Cg)-Pitpnavb x A/J)F2-Pitpnavb/Pitpnavb animals using survival beyond 42 days (the maximum survival observed among B6.D2(Cg)-Pitpnavb animals) as a dichotomous trait and using survival latency in days as a quantitative trait. Animals were drawn from two equivalent but independent crosses performed in 2003-2004 (81 vb/vb) and 2007-2008 (140 vb/vb), with similar phenotype distributions. The authors genotyped 45 long-lived (approx. 49 days) and 42 short-lived (approx 41 days) animals biased for extreme survival times and including all of the longest-lived. QTL were mapped using using microsatellite (SSLP) markers. Development of additional markers, to distinguish A/J and C57BL/6J alleles in a long segment of low divergence on chromosome 10, was guided by segments containing SNP polymorphisms in published maps (Pletcher et al. 2004). The authors identified three QTL reaching genome-wide significance: QTL Mvb2 (modifier of vibrator 2) is significant for the dichotomous trait of survival past 42 days. It maps to Chromosome 10 with a peak LOD score at D10Mit233. Mvb2 shows a semidominant survival effect with AA > AB > BB genotypes. QTL Mvb3 (modifier of vibrator 3) is significant for the dichotomous trait of survival past 42 days. It maps to Chromosome 3 with a peak LOD at D3Mit315. Mvb3 shows molecular heterosis with AB > AA or BB.QTL Mvb4 (modifier of vibrator 4) is significant for the quantitative trait of survival latency. It maps to Chromosome 10 with a peak LOD at D10Mit233. Mvb4 shows a semidominant survival effect witih AA > AB > BB genotypes. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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