Hotair^tm1Vlcg
Targeted Allele Detail

Summary

• Symbol: Hotair^tm1Vlcg
• Name: HOX transcript antisense RNA (non-protein coding); targeted mutation 1, Velocigene
• MGI ID: MGI:5790422
• Synonyms: Hotair^-
• Gene: Hotair Location: Chr15:102852494-102856165 bp, - strand Genetic Position: Chr15, 58.01 cM
• Alliance: Hotair^tm1Vlcg page

Homeotic transformation in the 4th caudal vertebra of Hotair^tm1Vlcg/Hotair^tm1Vlcg mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233815
• Parent Cell Line: VGF1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination replaced the entire 2.3 kb gene with a lacZ reporter cassette (including Kozak sequence and ATG start codon) and a loxP site flanked neomycin resistance gene cassette. (J:233815)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hotair Mutation: 2 strains or lines available

References

• Original: J:233815 Lai KM, et al., Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. PLoS One. 2015;10(4):e0125522
• All: 2 reference(s)