Slc25a5^tm1.1Nte
Targeted Allele Detail

Summary

• Symbol: Slc25a5^tm1.1Nte
• Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5; targeted mutation 1.1, Naohiro Terada
• MGI ID: MGI:5790470
• Synonyms: ANT2^2f
• Gene: Slc25a5 Location: ChrX:36059304-36062460 bp, + strand Genetic Position: ChrX, 21.2 cM, cytoband A4
• Alliance: Slc25a5^tm1.1Nte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234617
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and an FRT-splice donor/acceptor-IRES-beta-gal/neo-FRT-loxP downstream of exon 3. ES cells were transiently transfected with a FLP-expressing plasmid to remove the SA-IRES-betageo cassette leaving exons 2-3 floxed. (J:234617)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc25a5 Mutation: 8 strains or lines available

References

• Original: J:234617 Cho J, et al., Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ. 2015 Sep;22(9):1437-50
• All: 4 reference(s)