Ell2^tm1.1Cmil
Targeted Allele Detail

Summary

• Symbol: Ell2^tm1.1Cmil
• Name: elongation factor for RNA polymerase II 2; targeted mutation 1.1, Christine Milcarek
• MGI ID: MGI:5790670
• Synonyms: ELL2 cKO, ELL2 exon 3 loxp, ELL2^loxp
• Gene: Ell2 Location: Chr13:75855603-75920480 bp, + strand Genetic Position: Chr13, 40.93 cM
• Alliance: Ell2^tm1.1Cmil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 3, and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 3 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 3 floxed. (J:234692)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ell2 Mutation: 43 strains or lines available

References

• Original: J:234692 Park KS, et al., Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. J Immunol. 2014 Nov 1;193(9):4663-74
• All: 3 reference(s)